start:classes:principlesofdesign:biolung:bill_of_goods

2012-01-24T17:23:41-04:00

See below document for excel spreadsheet detailing items to be purchased: [Materials to be Purchased] Edited: January 12, 2012 Older Versions [Materials to be Purchased] Edited: November 8, 2011 [Materials to be Purchased] Edited: October 27, 2011

start:classes:principlesofdesign:biolung:click_here_to_see_a_detailed_list_of_pumps

2011-02-12T23:24:11-04:00

Pumps There are three basic types of pumps that are relevant to us: the positive displacement, centrifugal, and peristaltic pumps. Within each category there are several different pumps that will be discussed below. The basic concept of the positive displacement pumps is that they create some sort of cavity using pressure to pull the substance into the cavity and then force it out. Centrifugal pumps apply a centrifugal force to push fluids through the system. Peristaltic pumps force the substan…

start:classes:principlesofdesign:biolung:click_here_to_see_our_class_homeworks

2011-05-03T17:29:17-04:00

Yaron Tokayer Julain Alvarez Elli Rappaport

start:classes:principlesofdesign:biolung:click_here_to_see_our_team_s_busy_schedule

2011-02-13T18:41:03-04:00

Monday Tuesday Wednesday Thursday Friday 9:00 XXXX XXXX XXXX XXXX XXXX 10:00 XXXX XXXX XXXX XXXX XXXX 11:00 XXXX XXXX EID 103 XXXX XXXX 12:00 XXXX XXXX XXXX XXXX XXXX 1:00 XXXX XXXX XXXX XXXX XXXX 2:00 XXXX EID 103 XXXX XXXX XXXX 3:00 XXXX XXXX XXXX XXXX 4:00 XXXX XXXX XXXX 5:00 XXXX XXXX XXXX 6:00 XXXX XXXX XXXX XXXX XXXX 7:00 XXXX XXXX XXX…

start:classes:principlesofdesign:biolung:click_here_to_see_pump_research

2011-02-12T22:05:37-04:00

There are three basic types of pumps that are relevant to us: the positive displacement, centrifugal, and jet pumps. Within each category there are several different pumps that will be discussed below. The basic concept of the positive displacement pumps is that they create some sort of cavity using pressure to pull the substance into the cavity and then force it out. Centrifugal pumps apply a centrifugal force to push fluids through the system. Jet pumps force the substance through a nozzle in …

start:classes:principlesofdesign:biolung:details_on_pumps_to_be_used_for_negative_pressure

2011-06-22T14:59:20-04:00

The following information is what we are currently using for the negative pressure system. However, (unlike explained below) we will be using a single pump and connecting the pump to 2 different lung chambers in series. Computer compatible drive: 07551-00 - Computer Software: 07550-74 - Computer Cable: 22050-54 (RS-232 to RS-232) -

start:classes:principlesofdesign:biolung:e-mailed

2011-07-14T16:05:58-04:00

I've attached a video of two of the check valves not working. You will see a bag full of a green liquid and a bag of the clear water both connected to a Y-connector and then through a peristaltic pump and then into a separate container. The clear water is connected using a check-valve placed in the correct direction (so it should allow water to flow freely to the container on the other side of the pump), the green fluid is placed such that the check valve should block all flow through the pump…

start:classes:principlesofdesign:biolung:heating

2011-03-21T21:26:09-04:00

Heating Methodology Since direct exposure of the perfusate to the heating elements could result in the compromise of the said substances due to uneven heating, it is not recommended. Therefore an indirect method must be determined to prevent the possible seperate the perfusate. This involves conducting the heating element's heat through a secondary substance before it can be transferred to the perfusate. For this there are two methods:

start:classes:principlesofdesign:biolung:here

2011-04-11T10:08:56-04:00

start:classes:principlesofdesign:biolung:materials_to_be_purchased

2011-07-14T13:35:15-04:00

Materials Needed * Food coloring {Purchased 6/29/2011} * can be used to test our tubing set-up * maybe one color to represent each SDS, saline, and recellularizing media (and blood) * More panel mount connectors * we never ordered enough for bags * we would need more of the ones with the threading for now because multiple bags can be used in one tubing

start:classes:principlesofdesign:biolung:media_reservoirs

2011-04-17T23:35:40-04:00

Media Reservoirs We will be using 1-liter reservoirs to hold the media required for the process. The reservoirs can either be bag or bottle reservoirs that come with the proper included tubes and attachments. We have not yet found exactly what will be used, but the following links are to pages similar to what we will need and be using: These are the bottles that could be sued to store 1 liter of media: These are lids tha…

start:classes:principlesofdesign:biolung:minutes

2011-11-07T10:35:17-04:00

Wednesday January 26, 2011 Meeting with Prof. Lima and Columbia surgeons scheduled for Friday at 4:00 pm Plans to update wiki page. Friday January 28, 2011 Columbia surgeons back out on meeting. Rescheduled for Tuesday at 5:00 pm. One student member of the group will join Prof. Lima and take notes for the group.

start:classes:principlesofdesign:biolung:old_designs

2011-08-02T10:15:38-04:00

[Explanation of Lung Bioreactor Diagram]

start:classes:principlesofdesign:biolung:our_current_qfd_sheet

2011-02-14T10:16:02-04:00

start:classes:principlesofdesign:biolung:pictures_of_some_of_our_subsystems

2011-04-17T22:53:06-04:00

[3-Way Switcher] [Pump Drive & Pump Heads] [Y-Connector] [Panel Mount Connector] For details on our plans for the 3-Way Switcher, Y-Connector, Check Valves, and Panel Mount Connectors see the appropriate articles in Tubes and Valves. For details on our pump plans see Details on Pumps to be used for Negative Pressure.

start:classes:principlesofdesign:biolung:pictures_of_the_air-bleed_system

2012-02-17T02:35:19-04:00

start:classes:principlesofdesign:biolung:project_progress

2012-03-12T14:21:39-04:00

May 23, 2011 The panel mount connectors were water-proofed using rubber o-rings and silicone rubber sealant Tried inflating balloons using negative pressure – no success because the balloons were too resistant; after stretching out the balloons several times still very little response

start:classes:principlesofdesign:biolung:pumps

2011-08-11T12:41:12-04:00

The following is a list of general information on pump types; for details on the pumps we will be using see our design section of the wiki. There are three basic types of pumps that are relevant to us: the positive displacement, centrifugal, and jet pumps. Within each category there are several different pumps that will be discussed below. The basic concept of the positive displacement pumps is that they create some sort of cavity using pressure to pull the substance into the cavity and then fo…

start:classes:principlesofdesign:biolung:sensors

2011-07-25T14:59:42-04:00

We need sensors to monitor temperature of the fluids and the lung chamber, flow rate of both the trachea and blood vessel fluids and air flow rate through trachea, and pH levels in order to confirm that nothing has been contaminated and to note at what point the lung has properly been rinsed of the SDS decullarizing detergent.

start:classes:principlesofdesign:biolung:start

2011-09-27T18:57:46-04:00

THIS WEBPAGE IS NO LONGER KEPT UP TO DATE. FOR THE UPDATED WEBPAGE ON OUR BIOREACTOR GO TO Lung Bioreactors. DO NOT UPDATE THIS WIKI, AS ANY UPDATES TO THIS WIKI WILL NOT BE SEEN BY THE LUNG BIOREACTOR EXTRAORDINAIRES Anthony Assal, Julian Alvarez, Malcolm Dell, Elli Rappaport, Yaron Tokayer

start:classes:principlesofdesign:biolung:the_lung

2011-03-18T14:50:43-04:00

The Lung When the lungs are upright, ventilation is greatest at the bases. Also, the blood is most concentrated at the bases (just as veinal volume is greatest in the feet). This is the main difference between keeping the lungs upright and laid down. However, this shouldn't make a practical difference for us because during fetal development the baby is upside down, and even adults often lie down and breath normally. On of the most difficult and most important things to mindful of is that th…

start:classes:principlesofdesign:biolung:this_picture

2011-04-11T20:05:14-04:00

start:classes:principlesofdesign:biolung:tubes_and_valves

2011-08-18T22:06:06-04:00

Tubes Main tube requirements are that they are antimicrobial to prevent contamination of the lung while inside the bioreactor. Ideally medical tubing normally used for cardiac surgery since it is easy to sterilize and is designed to work with blood. Other microbial tubes use silver lining on the areas in contact with fluid to prevent growth of mildew and biofilm. The tubing will have to be capable of avoiding contamination for the entire time interval the lung is in the bioreactor. Columbi…

Cooper Union Open Source start:classes:principlesofdesign:biolung